If symptoms are mild, treatment is unnecessary as the condition resolves within 3 weeks. It may be tempting to put warm compresses on the breasts or wrap them to prevent milk leakage causing stains in the house. It is important to remember that any touching of the mammary tissue is what stimulates milk production so it is important to minimize tactile stimulation. If the female is licking herself, she may need an Elizabethan collar to minimize stimulation.
If a more aggressive approach is needed, a diuretic such as furosemide can be prescribed. The idea is that mild dehydration will end the lactation. Some people may want to try water deprivation but this is potentially dangerous and should not be attempted without specific veterinary guidance.
If this doesn’t work, hormonal medications can be used. Progesterone can be used but after the course of medication is complete, the false pregnancy recurs so this is not a good choice. Estrogens are also not a good choice as they bring the dog back into estrus symptoms. A week’s course of the male hormone mibolerone has generally been successful but the medication is no longer available.
Hormones that inhibit prolactin (the hormone of milk production) are currently the best choices when medications are needed. Bromocryptine can be obtained from a compounding pharmacy and given until lactation ceases (about a week or two) but tends to cause upset stomach. Cabergoline has fewer side effects but is given similarly and tends to be more expensive. Both these medications will cause abortion if the dog actually turns out to be pregnant so it is important to be sure.